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Bio-Spun™ Scaffolds: A Reliable, 100% Animal-Free Solution for 3D Cell Culture

Bio-Spun™ Scaffolds are engineered to replace the body's natural extracellular matrix without relying on animal-derived materials, offering a fully animal-free model with enhanced reliability and consistency.

BioSurfaces also provides tailored solutions, integrating our scaffolds across a variety of 3D bioprinting, organ-on-chip, and cell therapy applications. Using our proprietary process, we can incorporate drugs, growth factors, or other bioactive agents directly into the Bio-Spun™ scaffold—helping customers achieve targeted cellular effects as needed.

Current Tissue Models Made with Bio-Spun™ Scaffolds

Skin Model

H&E-stained cross section of full thickness human skin model produced on Bio-Spun™ PET Scaffold. Extracellular matrix proteins produced by keratinocytes and fibroblasts self-assemble to form a robust dermal component and basement membrane structures. The epidermis contains a uniform basal keratinocyte layer, granular cell layer, and stratum corneum layer with in vivo-like barrier function.

Airway Model

H&E-stained cross section of full-thickness human bronchial epithelial model produced on Bio-Spun™ PET Scaffold. The scaffold is populated with pulmonary fibroblasts which produce a fully human derived subepithelial matrix component. The fully developed pseudostratified mucociliary epithelium contains basal, goblet and ciliated cells with functional tight junctions.

Intestinal Model

H&E-stained cross section of human Intestinal epithelial model produced on Bio-Spun™ PDLGA Scaffold. The stratified differentiated intestinal epithelium contains villi- and crypt-like structures, contains enterocytes, goblet cells, and Paneth cells and develops functional tight junctions.

Retinal Model

SEM magnified cross section of fully functional outer-blood-retina-barrier (oBRB) produced on Bio-Spun™ PDLGA Scaffold. This image represents 6-week-old cultured tissues containing capillaries (cl), RPE, and Bruch’s membrane. Scale bar, 10 μm.

With Bio-Spun™ Scaffolds, you gain a cutting-edge, customizable, and ethical alternative to traditional scaffolding methods—designed to improve consistency and results across all your 3D cell culture applications. Whether you’re advancing research, developing therapeutics, or creating complex cellular models, BioSurfaces is here to support your goals with innovative, animal-free solutions that push the boundaries of what’s possible in cell culture. Choose Bio-Spun™ for unmatched performance and a partner committed to your success. If you're interested in learning more about our process or exploring a potential partnership, click the "Contact Us" button below!

Spin Cycle Your Monthly Hub for Fresh Insights and Updates

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Your Monthly Hub for Fresh Insights and Updates