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Bio-Spun Fistula Plug.jpg
Bio-Spun™ Fistula Plug

Innovative Approaches to Complex Fistulas:

BioSurfaces introduces an off-the-shelf, acellular cutting-edge solution for the treatment of various fistulas, offering a minimally invasive and efficacious option designed to improve outcomes. Our Bio-Spun™ technology promotes tissue integration, resulting in reduction of scarring while improving device anchoring

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Applications for Bio-Spun™ Fistula Plug

  • Perianal Fistulas: Anal fistulas such as cryptoglandular fistulas (~1.2 million worldwide) remain a major source of morbidity

  • Enterocutaneous Fistulas: Common complications from abdominal surgeries (e.g., pancreatitis, trauma, malignancy, IBD) affecting up to 25% of patients. Bio-Spun™ creates a biomaterial barrier, fortifying the boundary between the intestine and skin.

  • Rectovaginal Fistulas: Incidence of 5% in Crohn’s disease patients. Our approach leverages biomaterial and potential cell-based therapies to enhance healing and minimize invasive procedures.

Learn More About Fistulas and Our Bio-Spun™ Fistula Plug

Animation by Life Sciences Animations

Preclinical Results: Superior Tissue Integration

  • Bio-Spun™ Fistula Plug demonstrated excellent tissue infiltration into both the tract and the device wall, resulting in tract healing

  • Bio-Spun™ Fistula Plug had full tissue integration and healing at the sphincter insertion site within 30 days, securely closing the tract entrance

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Market Insights

  • A large pharmaceutical company partner funded a blind survey of 15 surgeons

  • Dissatisfied with current fistula treatments, citing mediocre success rates (~50-60%) of current option and complications from more invasive surgical techniques

  • Seeking low-risk, minimally invasive options with reproducible results

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Key Benefits of Bio-Spun™ Fistula Plug

  • Off-the-shelf, acellular option for minimally invasive procedure

  • High tissue integration for improved tract healing

  • Better anchoring of device = less repeat procedures

  • Potential for drug (i.e. antibiotic, anti-inflammatory) and/or stem cell delivery 

Contact Us to Learn More About How Bio-Spun™ Technology Can Be Applied for Fistula Treatment

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