Bio-Spun™ Scaffolds
Your Solution to 100% Human Relevant Data in an In Vitro Environment

Airway Model

H&E-stained cross section of full-thickness human bronchial epithelial model produced on Bio-Spun™ PET Scaffold. The scaffold is populated with pulmonary fibroblasts which produce a fully human derived subepithelial matrix component. The fully developed pseudostratified mucociliary epithelium contains basal, goblet and ciliated cells with functional tight junctions.

Intestinal Model

H&E-stained cross section of human Intestinal epithelial model produced on Bio-Spun™ PDLGA Scaffold. The stratified differentiated intestinal epithelium contains villi- and crypt-like structures, contains enterocytes, goblet cells, and Paneth cells and develops functional tight junctions.

Retinal Model

SEM magnified cross section of fully functional outer-blood-retina-barrier (oBRB) produced on Bio-Spun™ PDLGA Scaffold. This image represents 6-week-old cultured tissues containing capillaries (cl), RPE, and Bruch’s membrane. Scale bar, 10 μm.

Skin Model

H&E-stained cross section of full thickness human skin model produced on Bio-Spun™ PET Scaffold.  Extracellular matrix proteins produced by keratinocytes and fibroblasts self-assemble to form a robust dermal component and basement membrane structures. The epidermis contains a uniform basal keratinocyte layer, granular cell layer, and stratum corneum layer with in vivo-like barrier function.